5-Fluorouracil → Tegafur

HRID 127685

Reaktionsgleichung

Reaktionsgleichung von HRID 127685
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[O:10]1[CH:14]=[CH:13][CH2:12][CH2:11]1>CN(C)C=O>[O:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[N:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:9])[NH:4][C:5]1=[O:8]

Komponenten

4

Edukt 2

HCID 33855-Fluorouracil2×HCID 709342,3-Dihydrofuran

Produkt 1

HCID 5386TegafurAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In 20 ml of dimethylformamide were dissolved 1.3 g of 5-fluorouracil. To this solution were added 1.4 g of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 5 hours at 170° C. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 1 whereby 0.35 g of the starting 5-fluorouracil was recovered as a substance insoluble in chloroform and 1.20 g of 1-(2-tetrahydrofuryl)-5-fluorouracil were obtained. The yield of the end product was 82% based on the consumed 5-fluorouracil.

Aufarbeitung

  1. customthe mixture was reacted in an autoclave for 5 hours at 170° C
  2. customAfter completion of the reaction
  3. customthe reaction liquid
  4. additionwas treated in the same manner
  5. customwas recovered as a substance insoluble in chloroform

Quellen und Nachweise

ORD-Eintrag
ord-b5e6adffeaf9477c8ac80bc7116060af
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256885

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