3-Amino-1-propanol → [2-(3-Hydroxypropyl)amino-2-oxoethoxy]acetic acid

HRID 127730

Reaktionsgleichung

Reaktionsgleichung von HRID 127730
CS([O-])(=O)=O.[C:6]1(=[O:13])[O:12][C:10](=[O:11])[CH2:9][O:8][CH2:7]1.[NH2:14][CH2:15][CH2:16][CH2:17][OH:18]>>[OH:18][CH2:17][CH2:16][CH2:15][NH:14][C:10](=[O:11])[CH2:9][O:8][CH2:7][C:6]([OH:12])=[O:13]

Komponenten

4

Edukt 3

HCID 90863-Amino-1-propanolHCID 782321,4-Dioxane-2,6-dioneHCID 85257Methanesulfonate

Produkt 1

HCID 20558885[2-(3-Hydroxypropyl)amino-2-oxoethoxy]acetic acid

Versuchsvorschrift

methanesulfonate by (a) reacting diglycolic anhydride and 3-aminopropanol to produce [2-(3-hydroxypropyl)amino-2-oxoethoxy]acetic acid, (b) heating to cyclize the latter to obtain 4-(3-hydroxypropyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 3-(3,5-dioxomorpholino)propyl methanesulfonate and (d) reacting the mesylate with 4-[bis(2-bromo-p-tolyl)methyl]piperidine.

Quellen und Nachweise

ORD-Eintrag
ord-98f30747ac314423a4756d58ce1a3a28
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256891

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