Ammonia → Benzamide
Reaktionsgleichung
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[OH-].C([Sn+2]Cl)CCC.[NH3:18]>>[C:1]([NH2:18])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 165 °C
Versuchsvorschrift
To demonstrate the ability to conduct the amidation in an inert reaction medium 400 gms. benzoic acid was dissolved in 400 mls. mineral spirits with 2 gms. butylchlorotin dihydroxide. The solution was then heated with agitation to 165° C. while introducing ammonia below the surface ofthe liquid through a dispersion tube at a rate of 0.5 SCFH. As the reactionprogressed the amide product came out of solution. An acid value of 12 was achieved after only 7 hours reaction. At the completion of the reaction the insoluble amide product was recovered by filtration, washed and dried.Benzamide (melt point 133°-135° C.) obtained by this process is substantially free of undesirable nitrile by-product.