Sulfuric Acid → HCID 23454145, Verbindung

HRID 1277480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1277480
[C:1]1(=[O:14])[N:5]([CH2:6][C:7]#[N:8])[C:4](=[O:9])[C:3]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:2]12.[CH3:15][C:16](O)([CH2:18][CH:19]([CH3:23])[CH2:20][CH2:21][CH3:22])[CH3:17].S(=O)(=O)(O)[OH:26]>C(O)(=O)C>[C:4]1(=[O:9])[N:5]([CH2:6][C:7]([NH:8][C:16]([CH3:17])([CH3:15])[CH2:18][CH:19]([CH3:23])[CH2:20][CH2:21][CH3:22])=[O:26])[C:1](=[O:14])[C:2]2=[CH:13][CH:12]=[CH:11][CH:10]=[C:3]12

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 345881N-(Cyanomethyl)-phthalimideHCID 5221872,4-Dimethylheptan-2-ol

Produkt 1

HCID 23454145HCID 23454145, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2-Phthalimidoacetonitrile (3.85 g) was dissolved in glacial acetic acid at 70° and 2,4-dimethylheptan-2-ol (3 g) was added; followed dropwise by conc. sulphuric acid (2.8 ml) the temperature being maintained between 65° and 70°. The final mixture was stirred for 15 minutes and then added slowly to ice cold water (150 ml). The resulting solid was collected, washed with water and dried in vacuo. It was dissolved in hot benzene, a little insoluble material filtered off and light petroleum (b.p. 40°-60° ) added to give 2-phthalimido-N-(1,1,3-trimethylhexyl)acetamide as a colourless solid, m.p. 131.6°.

Aufarbeitung

  1. temperaturebeing maintained between 65° and 70°
  2. customThe resulting solid was collected
  3. washwashed with water
  4. customdried in vacuo
  5. dissolutionIt was dissolved in hot benzene
  6. filtrationa little insoluble material filtered off
  7. additionlight petroleum (b.p. 40°-60° ) added

Quellen und Nachweise

ORD-Eintrag
ord-336a86f956ff426da5e66c4eb9c0ba39
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04277498

Notizen zur Reaktion

Wird geladen…