Hydrochloric Acid → Methyl alpha-methylthio-alpha-(m-benzoylphenyl)propionate

HRID 1277782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1277782
[CH3:1][S:2][C:3]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](OC)([O:22]C)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:10]=1)([CH3:8])[C:4]([O:6][CH3:7])=[O:5].COCCOC.O.Cl>C(Cl)Cl>[CH3:1][S:2][C:3]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](=[O:22])[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:10]=1)([CH3:8])[C:4]([O:6][CH3:7])=[O:5]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 80711,2-DimethoxyethaneHCID 12819452Methyl alpha-methylthio-alpha-(m-(alpha,alpha-dimethoxybenzyl)phenyl)propionate

Produkt 1

HCID 13020172Methyl alpha-methylthio-alpha-(m-benzoylphenyl)propionateAusbeute 102,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 978 mg of methyl α-methylthio-α-[m-(α,α-dimethoxybenzyl)phenyl]propionate were added 2 ml of 1,2-dimethoxyethane and 0.5 ml of water, and 0.2 ml of conc. hydrochloric acid was further added. The mixture was stirred at room temperature for 15 hours. The reaction solution was diluted with 50 ml of methylene chloride, and dried over anhydrous sodium sulfate. The drying agent was separated by filtration, and the filtrate was concentrated under reduced pressure to afford 874 mg of methyl α-methylthio-α-(m-benzoylphenyl)propionate. The product was found to be substantially pure by its NMR and GLC.

Aufarbeitung

  1. additionwas further added
  2. dry with materialdried over anhydrous sodium sulfate
  3. customThe drying agent was separated by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cada97a3b7674a799a1ef6838417858e
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04278802

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