CO.O.Cl.CS[C:7]([C:13]1[CH:18]=[CH:17][C:16]([C:19](OC)([O:25]C)[C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)=[CH:15][CH:14]=1)([CH3:12])[C:8]([O:10][CH3:11])=[O:9]>C(Cl)Cl>[S:21]1[CH:22]=[CH:23][CH:24]=[C:20]1[C:19]([C:16]1[CH:17]=[CH:18][C:13]([CH:7]([CH3:12])[C:8]([O:10][CH3:11])=[O:9])=[CH:14][CH:15]=1)=[O:25]Methanol (4 ml), 1 ml of water, and 0.2 ml of conc. hydrochloric acid were added to 405 mg of methyl α-methylthio-α-[p-[dimethoxy(2-thienyl)methyl]phenyl]propionate, and the resulting mixture was heated under reflux for 30 minutes. After the mixture was cooled and shaken with 50 ml of methylene chloride, the organic layer was separated, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 320 mg of methyl α-[p-(2-thienylcarbonyl)phenyl]propionate as a colorless oil in a yield of 90%.
Wird geladen…
