Sodium borohydride → HCID 21163070, Verbindung

HRID 1278211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278211
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH:16]=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[BH4-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH2:16][OH:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 21163078HCID 21163078, Verbindung

Produkt 1

HCID 21163070HCID 21163070, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2.0 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine-3-carboxaldehyde and 0.35 g. of sodium borohydride in 100 ml. of methanol is stirred for 16 hours. The mixture is concentrated to dryness in vacuo and dichloromethane is added. The solution is washed with saturated sodium bicarbonate and passed through a column of hydrous magnesium silicate. The eluent is concentrated and diluted with hexane to give the product of the example.

Aufarbeitung

  1. additionA mixture of 2.0 g
  2. concentrationThe mixture is concentrated to dryness in vacuo and dichloromethane
  3. additionis added
  4. washThe solution is washed with saturated sodium bicarbonate
  5. concentrationThe eluent is concentrated
  6. additiondiluted with hexane
  7. customto give the product of the example

Quellen und Nachweise

ORD-Eintrag
ord-d8dab2706e6a4c42ad1893aae81e8fd3
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281000

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