Sulfuric Acid → 3-Chloro-4-fluoro-N-methylaniline

HRID 127822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 127822
[Cl:1][C:2]1[CH:3]=[C:4]([N:9](C)[CH:10]=O)[CH:5]=[CH:6][C:7]=1[F:8].S(=O)(=O)(O)O>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[NH:9][CH3:10]

Komponenten

4

Edukt 2

HCID 1118Sulfuric AcidHCID 12876631N-(3-chloro-4-fluorophenyl)N-methylformamide

Produkt 1

HCID 128766323-Chloro-4-fluoro-N-methylaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

A mixture of 42.2 g of 5A and 50 g of concentrated sulfuric acid in 600 ml of water was refluxed for 7 hours. The resulting mixture was charcoaled, filtered, cooled to 10° C. and made alkaline with sodium hydroxide. The resulting mixture was extracted with ether. The extract was dried and the ether evaporated to give 3-chloro-4-fluoro-N-methyl-aniline, (5B), as a yellow oil.

Aufarbeitung

  1. temperaturewas refluxed for 7 hours
  2. filtrationfiltered
  3. extractionThe resulting mixture was extracted with ether
  4. customThe extract was dried
  5. customthe ether evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a95517720cb2420d9d6caa979bbb692f
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04257805

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