Sodium Hydroxide → 4,4'-((4-((3-(4-Morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine

HRID 1278338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278338
CC1C=CC(S(O)(=O)=O)=CC=1.CC1C=CC(S(O)(=O)=O)=CC=1.Cl[C:24]1[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35][N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)(=[O:32])=[O:31])=[CH:26][C:25]=1[S:42]([CH2:45][CH2:46][CH2:47][N:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1)(=[O:44])=[O:43].Cl.[N:55]1([CH2:61][CH2:62][CH2:63][S:64]C(=N)N)[CH2:60][CH2:59][O:58][CH2:57][CH2:56]1.[OH-].[Na+]>O>[N:55]1([CH2:61][CH2:62][CH2:63][S:64][C:24]2[CH:29]=[CH:28][C:27]([S:30]([CH2:33][CH2:34][CH2:35][N:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)(=[O:32])=[O:31])=[CH:26][C:25]=2[S:42]([CH2:45][CH2:46][CH2:47][N:48]2[CH2:53][CH2:52][O:51][CH2:50][CH2:49]2)(=[O:44])=[O:43])[CH2:60][CH2:59][O:58][CH2:57][CH2:56]1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 21163758HCID 21163758, VerbindungHCID 21163760HCID 21163760, Verbindung

Produkt 1

HCID 211637644,4'-((4-((3-(4-Morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 5.0 g (0.0060 mole) of 4,4'-((4-chloro-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine bis(4-methylbenzenesulfonate), 1.4 g (0.0060 mole) of S-(3-(4-morpholinyl)propyl)isothiourea hydrochloride and 0.8 g (0.02 mole) of sodium hydroxide in 80 ml of water was heated under reflux with stirring for 3.5 hours, cooled and extracted with methylene chloride. The extract was dried over anhydrous sodium sulfate, and the solvent was removed by evaporation, leaving the product as 4,4'-((4-((3-(4-morpholinyl)propyl)thio)-1,3-phenylene)bis(sulfonyl-3,1-propanediyl))bismorpholine a yellow, viscous oil.

Aufarbeitung

  1. temperatureunder reflux
  2. temperaturecooled
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried over anhydrous sodium sulfate
  5. customthe solvent was removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-b4f67c3d4be24bf081206a6bc760a44c
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281118

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