Hydrochloric Acid → Ertiprotafib

HRID 1278825Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278825
C[O:2][C:3](=[O:37])[C@H:4]([O:12][C:13]1[C:18]([CH3:19])=[CH:17][C:16]([C:20]2[C:32]3[C:31]([CH3:33])=[C:30]([CH3:34])[S:29][C:28]=3[C:27]([Br:35])=[C:26]3[C:21]=2[CH:22]=[CH:23][CH:24]=[CH:25]3)=[CH:15][C:14]=1[CH3:36])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[K+].Cl>O1CCCC1.CO.O>[Br:35][C:27]1[C:28]2[S:29][C:30]([CH3:34])=[C:31]([CH3:33])[C:32]=2[C:20]([C:16]2[CH:15]=[C:14]([CH3:36])[C:13]([O:12][C@H:4]([CH2:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:3]([OH:37])=[O:2])=[C:18]([CH3:19])[CH:17]=2)=[C:21]2[C:26]=1[CH:25]=[CH:24][CH:23]=[CH:22]2

Komponenten

7

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 70157633HCID 70157633, Verbindung

Produkt 1

HCID 157049Ertiprotafib

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of (2R)-2-[4-(9-bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2,6-dimethyl-phenoxy]-3-phenyl-propionic acid methyl ester (3.1 g, 5.4 mmol) in tetrahydrofuran (125 mL) and methanol (41 mL) at room temperature was added dropwise aqueous potassium hydroxide (6.5 mL of a 1N solution, 6.5 mmol). After 1.5 h at room temperature the reaction mixture was placed in the freezer for 18 h. The reaction was removed from the freezer and allowed to stir at room temperature. More aqueous potassium hydroxide (19.5 mL of a 1N solution, 19.5 mmol) was added, and the reaction mixture was allowed to stir at room temperature for 9.5 h. Concentration under reduced pressure gave a residue which was diluted with water (1 L). The aqueous layer was acidified with concentrated hydrochloric acid to a pH of 1, and extracted with diethyl ether (700 mL). The diethyl ether layer was washed twice with water (500 mL), and then dried (Na2SO4). Concentration under reduced pressure and chromatography on silica gel (treated with 2% phosphoric acid in methanol) with petroleum ether:ethyl acetate (90:10, then 86:14) gave the title compound as a white solid foam (1.9 g, 64%): Opt. Rot. [a]25/D=+33.380 (10.035 mg/mL, MeOH); NMR (DMSO-d6): δ 12.90 (broad singlet, 1H), 8.17 (d, 1H), 7.63 (ddd, 1H), 7.50-7.43 (m, 2H), 7.36-7.23 (m, 5H), 6.97 (s, 2H), 4.71 (t, 1H), 3.25 (d, 2H), 2.41 (s, 3H), 2.24 (s, 3H), 2.21 (s, 3H), 1.54 (s, 3H); MS(EI): [M+], 1 bromine isotope pattern, 558/560; Anal. Calc. for C31H27BrO3S: C, 66.55, H, 4.86, N, 0.00. Found: C, 65.91, H, 5.05, N, 0.09; Analytical HPLC indicates a major component (99.5%).

Aufarbeitung

  1. customThe reaction was removed from the freezer
  2. additionMore aqueous potassium hydroxide (19.5 mL of a 1N solution, 19.5 mmol) was added
  3. stirringto stir at room temperature for 9.5 h
  4. concentrationConcentration under reduced pressure
  5. customgave a residue which
  6. extractionextracted with diethyl ether (700 mL)
  7. washThe diethyl ether layer was washed twice with water (500 mL)
  8. dry with materialdried (Na2SO4)
  9. concentrationConcentration under reduced pressure and chromatography on silica gel (treated with 2% phosphoric acid in methanol) with petroleum ether:ethyl acetate (90:10

Quellen und Nachweise

ORD-Eintrag
ord-0259d38b048c4e0c8fa615d912ac83a4
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06444670B2

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