Clarithromycin → Clarithromycin formate

HRID 1278899

Reaktionsgleichung

Reaktionsgleichung von HRID 1278899
[CH3:1][CH2:2][C@H:3]1[O:18][C:16](=[O:17])[C@H:15]([CH3:19])[C@@H:14]([O:20][C@@H:21]2[O:26][C@@H:25]([CH3:27])[C@H:24]([OH:28])[C@@:23]([O:30][CH3:31])([CH3:29])[CH2:22]2)[C@H:13]([CH3:32])[C@@H:12]([O:33][C@@H:34]2[O:39][C@H:38]([CH3:40])[CH2:37][C@H:36]([N:41]([CH3:43])[CH3:42])[C@H:35]2[OH:44])[C@@:11]([O:46][CH3:47])([CH3:45])[CH2:10][C@@H:9]([CH3:48])[C:7](=[O:8])[C@H:6]([CH3:49])[C@@H:5]([OH:50])[C@@:4]1([OH:52])[CH3:51]>C(O)=O>[CH3:1][CH2:2][C@H:3]1[O:18][C:16](=[O:17])[C@H:15]([CH3:19])[C@@H:14]([O:20][C@@H:21]2[O:26][C@@H:25]([CH3:27])[C@H:24]([OH:28])[C@@:23]([O:30][CH3:31])([CH3:29])[CH2:22]2)[C@H:13]([CH3:32])[C@@H:12]([O:33][C@@H:34]2[O:39][C@H:38]([CH3:40])[CH2:37][C@H:36]([N:41]([CH3:42])[CH3:43])[C@H:35]2[OH:44])[C@@:11]([O:46][CH3:47])([CH3:45])[CH2:10][C@@H:9]([CH3:48])[C:7](=[O:8])[C@H:6]([CH3:49])[C@@H:5]([OH:50])[C@@:4]1([OH:52])[CH3:51].[CH:16]([O-:18])=[O:17]

Komponenten

3

Edukt 1

HCID 84029Clarithromycin2×

Produkt 1

HCID 86758498Clarithromycin formate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

Specifically, clarithromycin is dissolved in an organic solvent at a temperature ranging from room temperature to the boiling point of the solvent for a period sufficient to make a solution or suspension. Then, formic acid, neat or dissolved in an organic solvent, is added to the solution or suspension in an amount ranging from 1 to 5 moles based on 1 mole of clarithromycin. The mixture may then be optionally kept at a temperature in the range of room temperature to the boiling point of the solvent for 10 minutes to 1 hour. The resulting mixture is cooled to a temperature in the range of −20° C. to room temperature for a period sufficient to precipitate formate crystals of clarithromycin. Finally, the precipitated crystals are filtered and dried in a conventional manner to give crystalline clarithromycin formate.

Aufarbeitung

  1. waitranging from room temperature to the boiling point of the solvent for a period
  2. additionis added to the solution or suspension in an amount
  3. waitThe mixture may then be optionally kept at a temperature in the range of room temperature to the boiling point of the solvent for 10 minutes to 1 hour
  4. temperatureThe resulting mixture is cooled to a temperature in the range of −20° C. to room temperature for a period sufficient
  5. customto precipitate formate crystals of clarithromycin
  6. filtrationFinally, the precipitated crystals are filtered
  7. customdried in a conventional manner

Quellen und Nachweise

ORD-Eintrag
ord-ebf02882d6074b4b95bfd90db55aacd0
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06444796B1

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