Lithium Hydroxide → 2-(Methylthio)pyrimidine-5-carboxylic acid

HRID 1278916Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278916
[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([O:11]CC)=[O:10])=[CH:5][N:4]=1.[Li+].[OH-]>O1CCOCC1>[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][N:4]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 10442716Ethyl 2-(methylthio)pyrimidine-5-carboxylate

Produkt 1

HCID 36317942-(Methylthio)pyrimidine-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

1 Eq. of 2-methylthio-5-ethoxycarbonylpyrimidine were dissolved in dioxane and, after addition of 2 eq. of 2N LiOH, stirred overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in EtOH. After addition of a stoichiometric amount of ethereal HCl, the solution was again evaporated to dryness. Water which was still present was removed by azeotropic drying with toluene once.

Aufarbeitung

  1. customThe solvent was then removed under reduced pressure
  2. dissolutionthe residue was dissolved in EtOH
  3. additionAfter addition of a stoichiometric amount of ethereal HCl
  4. customthe solution was again evaporated to dryness
  5. customWater which was still present was removed
  6. dry with materialby azeotropic drying with toluene once

Quellen und Nachweise

ORD-Eintrag
ord-b61b61bb60724619931a278e2bf614e6
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06444817B1

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