Hydrochloric Acid → 7-Methoxy-1-methylisoquinoline

HRID 127923Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 127923
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[CH:6]([N:8]([CH2:19][CH:20](OC)OC)S(C1C=CC(C)=CC=1)(=O)=O)[CH3:7].O1CCOCC1.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:25]([CH:20]=[CH:19][N:8]=[C:6]2[CH3:7])=[CH:26][CH:27]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 20523222HCID 20523222, Verbindung

Produkt 1

HCID 159337467-Methoxy-1-methylisoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 39.3 g. (0.1 mole) of 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)-N-tosyl-benzylamine, one liter of dioxane and 80 ml. of 6 N hydrochloric acid is refluxed for six hours and allowed to stand for sixteen hours. The mixture is poured into two liters of water and extracted with ether. The aqueous phase is made alkaline with concentrated ammonium hydroxide and extracted with chloroform. The chloroform extract is washed, dried and evaporated to yield 7-methoxy-1-methylisoquinoline.

Aufarbeitung

  1. additionA mixture of 39.3 g
  2. waitto stand for sixteen hours
  3. extractionextracted with ether
  4. extractionextracted with chloroform
  5. extractionThe chloroform extract
  6. washis washed
  7. customdried
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f7361eb8210f458ca9fdcddc43a7b065
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04258049

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