Isopropanol → 1-Isopropyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine

HRID 127957

Reaktionsgleichung

Reaktionsgleichung von HRID 127957
Cl.[NH2:2][NH2:3].C(=O)(O)[O-].[Na+].[S:9]([C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Cl:22])[C:16](Cl)=[O:17])(=[O:12])(=[O:11])[NH2:10].[CH:23](O)([CH3:25])[CH3:24]>O>[CH:23]([N:2]([C:13]1[CH:14]=[CH:15][CH:19]=[CH:20][CH:21]=1)[NH:3][C:16](=[O:17])[C:15]1[CH:19]=[CH:20][C:21]([Cl:22])=[C:13]([S:9](=[O:12])(=[O:11])[NH2:10])[CH:14]=1)([CH3:25])[CH3:24]

Komponenten

6

Edukt 4

HCID 3776IsopropanolHCID 115031Hydrazinium chlorideHCID 516892Sodium BicarbonateHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chloride

Produkt 1

HCID 155714981-Isopropyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Neutralization of the hydrazine hydrochloride of Example 2 was effected by stirring with 19.6 g (0.21 mol) sodium bicarbonate in 100 ml isopropanol. When gas evolution ceased (1 1/2hours) the system was cooled in an ice-water bath, and 25 g (0.1 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was added in several portions. Throughout this addition the temperature was maintained between 5° and 20° C. After the addition the reaction mixture was stirred at room temperature overnight. The reaction mixture was then cooled to 0°-5° C., diluted with 80 ml water, and stirred for 2 more hours.

Aufarbeitung

  1. custom(1 1/2hours)
  2. temperaturewas cooled in an ice-water bath
  3. additionThroughout this addition the temperature
  4. temperaturewas maintained between 5° and 20° C
  5. additionAfter the addition the reaction mixture
  6. temperatureThe reaction mixture was then cooled to 0°-5° C.
  7. stirringstirred for 2 more hours

Quellen und Nachweise

ORD-Eintrag
ord-c96e3283c3cb4de5bda47f48bca4b165
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04258059

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