Reaktionsgleichung
[C@@H]1(C2C=C3C(C=C(C(O)=O)C(=O)O3)=CC=2)O[C@H](CO)[C@H](O)[C@H](O)[C@H]1[OH:3].ON1C(=O)CCC1=O.[CH:34]1([N:40]=[C:41]=[N:42][CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>CN(C)C=O>[C:41]([NH:40][CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1)([NH:42][CH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1)=[O:3]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 3.68 g (0.01 mol) of 7-β-galactosylcoumarin-3-carboxylic acid, supra, 2.30 g (0.02 mol) of N-hydroxy-succinimide, and 2.27 g (0.011 mol) of dicyclohexylcarbodiimide in 25 ml of dimethylformamide (DMF) was stirred under argon at room temperature for 1 hour. A thick precipitate of dicyclohexylurea formed and was removed by filtration. The clear filtrate was combined with 2.52 grams (g) of the hydrochloride salt of N-(tert-butyloxycarbonyl)-1,6-hexanediamine [Stahl et al, J. Org. Chem. 43:2285(1976)]. The solution was cooled to 0° C. and 2.8 ml (2.02 g, 0.02 mol) of triethylamine was added. The reaction was allowed to stir at room temperature for 2 hours, then filtered to remove the precipitate of triethylamine hydrochloride. Evaporation of the DMF under reduced pressure gave an oily residue that was stirred for 15 minutes with 100 ml of 2 N hydrochloric acid. The heavy precipitate that formed was filtered, washed with water, and dried.
Quellen und Nachweise
- ORD-Eintrag
- ord-660c63795ae84d729b138f59f0f718ba
- Quelldatensatz
- uspto-grants-1981_03
- Patentnummer
- US04259233
Verknüpfte Notizen
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