Hydrochloric Acid → (3-Fluoro-4-methylpyridin-2-yl)methanamine dihydrochloride

HRID 1281903Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1281903
[C:1]([C:3]1[C:8]([F:9])=[C:7]([CH3:10])[CH:6]=[CH:5][N:4]=1)#[N:2].[ClH:11]>C(O)C.[Pd]>[ClH:11].[ClH:11].[NH2:2][CH2:1][C:3]1[C:8]([F:9])=[C:7]([CH3:10])[CH:6]=[CH:5][N:4]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 184233523-Fluoro-4-methylpyridine-2-carbonitrile

Produkt 1

HCID 18423353(3-Fluoro-4-methylpyridin-2-yl)methanamine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A stirred solution of 332 mg (2.44 mmol) of 2-cyano-3-fluoro4-methylpyridine 5-3 in 15 mL of ethanol and 0.61 mL (7.32 mmol) of conc. HCl was hydrogenated over 175 mg of 10% palladium on carbon at 55 psi for 16 h. The catalyst was removed by filtration and the solvents removed at reduced pressure to give 5-4 as a yellow solid: 1H NMR (CD3OD) δ 8.41 (d, 1H, 5.1 Hz), 7.54 (dd, 1H, 5.5, 5.5 Hz), 4.40 (s, 2H), 2.44 (s, 3H).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvents removed at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e83b94b3a16e4ab9ac6c7151a24609da
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06455532B1

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