Ammonia → 6-Amino-2-fluoronicotinamide

HRID 1281974Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1281974
[F:1][C:2]1[N:10]=[C:9](F)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12].O>C(N)=O>[NH2:12][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[N:10]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 962WaterHCID 105830482,6-Difluoropyridine-3-carboxamide

Produkt 1

HCID 105348946-Amino-2-fluoronicotinamideAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 713FormamideLösungsmittel

Versuchsvorschrift

A solution of 2,6-difluoronicotinamide (4.68 g, 0.029 mmol) in dry formamide (30 mL) is saturated with ammonia and allowed to stand at room temperature for 24 h. Water (50 mL) is added and the resultant precipitate is filtered off and washed well with water, to give 6-amino-2-fluoronicotinamide (1.41 g, 31%) mp 236-237° C. 1H NMR (DMSO) δ 7.89 (1H, dd, J=10.4, 8.4 Hz), 7.31, 7.16 (1H, 1H, 2 brs,), 6.93 (2H, brs), 6.36 (1H, dd, J=8.4, 2.4 Hz).

Aufarbeitung

  1. filtrationthe resultant precipitate is filtered off
  2. washwashed well with water

Quellen und Nachweise

ORD-Eintrag
ord-f903ef296693427ea73b456abaa6e93a
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06455534B2

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