Water → 4-Methoxy-2-(piperazin-1-yl)pyrimidine

HRID 1282167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1282167
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.O>C(#N)C>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 4837PiperazineHCID 5889352-Chloro-4-methoxypyrimidine

Produkt 1

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A suspension of 2-chloro-4-methoxypyrimidine (21.5 g) and piperazine (64.0 g) in acetonitrile (200 ml) was refluxed for 30 min. The reaction mixture was poured into water (500 ml) and extracted with chloroform (400 ml). The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound (26.0 g) as a pale-yellow oil.

Aufarbeitung

  1. temperaturewas refluxed for 30 min
  2. extractionextracted with chloroform (400 ml)
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5c2dcbca42a644a7b85acf3e1349d051
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06455528B1

Notizen zur Reaktion

Wird geladen…