Potassium Carbonate → HCID 54335838, Verbindung

HRID 128319Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 128319
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.C(=O)([O-])[O-].[K+].[K+].CN(C)P(N(C)C)(N(C)C)=O>O>[CH2:24]1[CH2:23][CH2:22][CH2:21][CH:20]([CH2:19][CH2:18][CH2:17][CH2:16][NH:1][C:2]2[CH:3]=[CH:4][C:5]([CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:13][CH:14]=2)[CH2:26][CH2:25]1

Komponenten

6

Edukt 4

HCID 11430Potassium CarbonateHCID 12679HexamethylphosphoramideHCID 97826Ethyl 3-(4-aminophenyl)acrylateHCID 13131543(4-Bromobutyl)cycloheptane

Produkt 1

HCID 54335838HCID 54335838, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of ethyl p-aminocinnamate, 5.9 g. 4-bromobutylcycloheptane and one equivalent of anhydrous powdered potassium carbonate in 50 ml. hexamethylphosphoramide is heated for 20 hours at 60° C. The mixture is then cooled, diluted with water and extracted with ether. The combined ether extracts are dried, filtered and evaporated. Crystallization from acetonitrile provides the title compound as white crystals.

Aufarbeitung

  1. temperatureThe mixture is then cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried
  4. filtrationfiltered
  5. customevaporated
  6. customCrystallization from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-066ba254822146d2a4d93aa6ba85e614
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04259352

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