Fluretofene → 4'-Ethenyl-2-fluoro-1,1'-biphenyl

HRID 1283634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1283634
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])=[CH:5][CH:4]=1)#[CH:2].[H][H]>[Pd].N1C=CC=CC=1>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[CH2:2])=[CH:8][CH:7]=1

Komponenten

5

Edukt 2

HCID 42040FluretofeneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 194261784'-Ethenyl-2-fluoro-1,1'-biphenyl

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 1049PyridineLösungsmittel

Versuchsvorschrift

1-Ethynyl-4-(2-fluorophenyl)benzene, 29.6 g., was reduced in a Parr Instrument Company Series 3910 Low-Pressure Shaker-Type Apparatus, using 450 ml. of pyridine, and 0.3 g. of five percent palladium on barium sulfate; reduction was carried out at room temperature for 30 minutes and at an initial hydrogen pressure of 30 psig. The reaction mixture was filtered and the filtrate was evaporated in vacuo. The residue was vacuum distilled to give 20.5 g. of solid which was recrystallized from methanol to give 4-(2 -fluorophenyl)-1-vinylbenzene, mp 38°. The material contained traces of pyridine and 1-ethyl-4-(2-fluorophenyl)benzene, as shown by nuclear magnetic resonance analysis. The following elemental analysis was obtained:

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated in vacuo
  3. distillationdistilled
  4. customto give 20.5 g
  5. customof solid which was recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-90923561189c4f22a426f7f44cfbbb1d
Quelldatensatz
uspto-grants-1976_08
Patentnummer
US03975543

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