Hydrazine hydrate (1:1) → 5-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

HRID 1284032Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1284032
C(O[C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)C.O.[NH2:17][NH2:18]>CO>[NH:17]([C:4]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]3[NH:14][CH:15]=[C:7]([C:8]=23)[CH2:6][N:5]=1)[NH2:18]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 215155225-Ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

Produkt 1

HCID 30410875-Hydrazino-1,3-dihydropyrrolo[4,3,2-de]isoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

A solution of 5-ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline (10.0 g), described in Example 5, in methanol (100 ml) is combined with a solution of hydrazine hydrate (3 g) in methanol (150 ml). After boiling overnight the mixture is concentrated to half of its original volume and diluted with ether. The resulting precipitate is collected to give the title compound, mp 188° - 189°C, νmaxnujol 3370, 3325, 3150, 1628, 1583, 1540 and 1510 cm-1.

Aufarbeitung

  1. concentrationthe mixture is concentrated to half of its original volume
  2. additiondiluted with ether
  3. customThe resulting precipitate is collected

Quellen und Nachweise

ORD-Eintrag
ord-b872ab6c2b594ecfb26287bca44f897b
Quelldatensatz
uspto-grants-1976_08
Patentnummer
US03978066

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