Acetone → 2-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

HRID 1284275Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1284275
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br)([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C-:21]#[N:22].[K+].CC(C)=O>O>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][C:21]#[N:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 9032Potassium CyanideHCID 203722852-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzyl bromide

Produkt 1

HCID 203722272-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2-(α,α,β ,β-Tetrafluorophenethyl)benzyl bromide, 3.5 g. (0.01 mole), and 2.0 g. (0.0308 mole) of potassium cyanide are dissolved in 35 ml. of acetone - 5 ml. of water and the solution is heated to refluxing for about 18 hours. The organic phase is separated, acetone is distilled under reduced pressure, and the residual oil is dissolved in benzene. Evaporation of the washed and dried benzene extract under reduced pressure leaves the product as the residual brown oil.

Aufarbeitung

  1. temperatureto refluxing for about 18 hours
  2. customThe organic phase is separated
  3. distillationacetone is distilled under reduced pressure
  4. dissolutionthe residual oil is dissolved in benzene
  5. customEvaporation of the
  6. washwashed
  7. extractiondried benzene extract under reduced pressure
  8. customleaves the product as the residual brown oil

Quellen und Nachweise

ORD-Eintrag
ord-ff7cbf6f41f344f09120b13f609ea1f9
Quelldatensatz
uspto-grants-1976_08
Patentnummer
US03978127

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