Methanol → HCID 10631783, Verbindung

HRID 1285527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1285527
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH2:12][CH3:13])[N:3]=1.CO.[CH3:16][NH2:17]>O>[CH2:12]([O:11][C:4]1[N:3]=[C:2]([NH:17][CH3:16])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1)[CH3:13]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 6329MethylamineHCID 202494082-Chloro-6-ethoxy-3-nitropyridine

Produkt 1

HCID 10631783HCID 10631783, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

In a stirred mixture consisting of 202.6 g (1 mole) of 2-chlor-6-ethoxy-3-nitropyridine and 500 ml of methanol, 202 g (2.6 mole) of a 40% monomethylamine solution is added drop by drop while stirring in the course of 90 minutes and at 25°-30° C. sump temperature. Subsequently, the mixture is again stirred for yet another 5 hours, is reacted with 650 ml of water, and then the product is filtered off by suction, is washed again with ample water and dried. Melting point 106°-7° C., Yield: 183.2 g (92.9% of theory).

Aufarbeitung

  1. additionis added drop by drop
  2. stirringSubsequently, the mixture is again stirred for yet another 5 hours
  3. filtrationthe product is filtered off by suction
  4. washis washed again with ample water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7e19216883ae4399b0ee6d2bf0bae1ec
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04567272

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