Sodium borohydride → HCID 21505599, Verbindung

HRID 1287638Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1287638
Cl([O-])(=O)(=O)=O.[F:6][C:7]1[CH:28]=[CH:27][C:10]([C:11]([CH2:13][CH2:14][CH2:15][N+:16]2[CH:21]=[CH:20][C:19]([C:22]3[O:23][CH:24]=[CH:25][N:26]=3)=[CH:18][CH:17]=2)=[O:12])=[CH:9][CH:8]=1.[BH4-].[Na+]>CO>[F:6][C:7]1[CH:28]=[CH:27][C:10]([CH:11]([OH:12])[CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH:18]=[C:19]([C:22]3[O:23][CH:24]=[CH:25][N:26]=3)[CH2:20][CH2:21]2)=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 713968301-[4-(4-Fluorophenyl)-4-oxobutyl]-4-(1,3-oxazol-2-YL)pyridin-1-ium perchlorate

Produkt 1

HCID 21505599HCID 21505599, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a 1.75 g. portion of 1-(3-p-fluorobenzoylpropyl)- 4-(2-oxazolyl)pyridinium perchlorate, prepared as described in Example 9, in 75 ml. of methanol, is added portionwise with stirring 1.75 g. of sodium borohydride. The mixture is stirred for 1 1/2 hours, allowed to stand, some of the methanol is evaporated and the mixture is poured into ice water causing the formation of a tan solid which is recovered by filtration, m.p. 100°-103° C.

Aufarbeitung

  1. stirringThe mixture is stirred for 1 1/2 hours
  2. customsome of the methanol is evaporated
  3. additionthe mixture is poured into ice water causing the formation of a tan solid which
  4. filtrationis recovered by filtration, m.p. 100°-103° C.

Quellen und Nachweise

ORD-Eintrag
ord-7ca063c490a34dc285b309b2e8df846a
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03985754

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