8-Chloroisoquinoline hydrochloride → 8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 1288455Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1288455
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2>[Pt](=O)=O.CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2

Komponenten

4

Edukt 1

HCID 123717488-Chloroisoquinoline hydrochloride

Produkt 1

HCID 125950728-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 11.0 g. of 8-chloroisoquinoline hydrochloride in 100 ml. of methanol was hydrogenated at atmospheric pressure over 0.5 g. of platinum dioxide as in Example 9. The mixture was filtered and concentrated to small volume. Ether was added, the mixture was filtered, and the solid recrystallized from ethanol to give 8-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 236°-238.5° C.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated to small volume
  3. additionEther was added
  4. filtrationthe mixture was filtered
  5. customthe solid recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-b7e4bf7f7c5744da94d828d68e6ac231
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03988339

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