Hydrochloric Acid → Tetrahydropyranyl bromomethyl-cyclohexyl ether

HRID 1289350Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1289350
[Br:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6](O)[CH2:5][CH2:4]1.[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH2:11]1.Cl.C(=O)([O-])[O-:18].[K+].[K+]>>[Br:1][CH2:2][C:3]1([O:18][CH:15]2[CH2:14][CH2:13][CH2:12][CH2:11][O:10]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 80803,4-dihydro-2H-pyranHCID 11430Potassium CarbonateHCID 218327074-(Bromomethyl)cyclohexan-1-ol

Produkt 1

HCID 21832708Tetrahydropyranyl bromomethyl-cyclohexyl ether

Versuchsvorschrift

4-Bromomethylcyclohexanol (C-5) (3.0 g) and dihydropyran (2.6 g) were mixed together and cooled with ice. A tiny drop of 10% hydrochloric acid was added. Exothermic reaction occurred and stirred at ambient temperature overnight. The solution was neutralized with potassium carbonate and extracted with dichloromethane (50 ml). It was filtered and then dichloromethane from the filtrate was evaporated to yield the compound C-6, tetrahydropyranyl bromomethyl-cyclohexyl ether (5.0 g).

Aufarbeitung

  1. temperaturecooled with ice
  2. customExothermic reaction
  3. extractionextracted with dichloromethane (50 ml)
  4. filtrationIt was filtered
  5. customdichloromethane from the filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8e0dbd93b09048068e94346ed1706d6b
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750300

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