2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → HCID 178485755, Verbindung

HRID 1290076Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290076
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.[C:51]([OH:63])(=[O:62])[CH2:52][C:53]([CH2:58][C:59]([OH:61])=[O:60])([C:55]([OH:57])=[O:56])[OH:54]>C(OCC)(=O)C>[C:51]([OH:63])(=[O:62])[CH2:52][C:53]([CH2:58][C:59]([OH:61])=[O:60])([C:55]([OH:57])=[O:56])[OH:54].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 178485751HCID 178485751, Verbindung

Produkt 1

HCID 178485755HCID 178485755, VerbindungAusbeute 66,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (3 ml) and a solution of citric acid monohydrate (92.7 mg) in ethyl acetate (5 ml) was dropwise added. After stirring at room temperature for 15 minutes, crystals were collected by filtration and dried under reduced pressure to give 257 mg of the title compound as white crystals (see Table 16).

Aufarbeitung

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ac2956440f2c436b8061b3693b6a8fb3
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750696

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