L-Tartaric acid → HCID 178485756, Verbindung

HRID 1290077Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290077
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:59])(=[O:58])[C@@H:51]([C@H:53]([C:55]([OH:57])=[O:56])[OH:54])[OH:52]>C(OCC)(=O)C.C(O)C>[C:55]([C@@H:53]([C@H:51]([C:50]([OH:59])=[O:58])[OH:52])[OH:54])([OH:57])=[O:56].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 444305L-Tartaric acidHCID 178485751HCID 178485751, Verbindung

Produkt 1

HCID 178485756HCID 178485756, VerbindungAusbeute 68,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (4.5 ml) and a solution of L-tartaric acid (66 mg) in ethyl acetate (5 ml) and ethanol (0.5 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 251 mg of the title compound as white crystals (see Table 16).

Aufarbeitung

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e6223c0ac8df4c57b301df180c926246
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750696

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