Maleic Acid → HCID 178485754, Verbindung

HRID 1290079Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290079
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54]>C(OCC)(=O)C.C(O)C>[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 444266Maleic AcidHCID 178485751HCID 178485751, Verbindung

Produkt 1

HCID 178485754HCID 178485754, VerbindungAusbeute 79,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

The compound (778 mg) obtained in Example 1 was dissolved in ethyl acetate (10 ml) and a solution of maleic acid (132 mg) in ethyl acetate (15.5 ml) and ethanol (1.55 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 723 mg of the title compound as white crystals (see Table 17).

Aufarbeitung

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-902c1afeed5b40b48f9435e57e378e33
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750696

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