Sodium Methoxide → 5-(Azidomethyl)tetrahydro-3-thiophenethiol
Reaktionsgleichung
[N:1]([CH2:4][CH:5]1[S:9][CH2:8][CH:7]([S:10]C(=O)C)[CH2:6]1)=[N+:2]=[N-:3].C[O-].[Na+]>CO>[N:1]([CH2:4][CH:5]1[S:9][CH2:8][CH:7]([SH:10])[CH2:6]1)=[N+:2]=[N-:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A 0° C. solution, under argon, of 0.279 g of product from Example 141 in 3 ml of dry methyl alcohol is treated with 0.35 ml of 4.35M sodium methoxide. After 2 hours, the reaction mixture is concentrated in vacuo and the residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane) to give 0.0465 g of the desired product.
Aufarbeitung
- concentrationthe reaction mixture is concentrated in vacuo
- customthe residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane)
Quellen und Nachweise
- ORD-Eintrag
- ord-90e8b35b34eb4995b566e18eb41e8d1b
- Quelldatensatz
- uspto-grants-1998_05
- Patentnummer
- US05750735
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