1-Chloro-1-penten-3-one → 7-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1290801Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290801
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.Cl[CH:8]=[CH:9][C:10](=O)[CH2:11][CH3:12]>C(O)(=O)C>[CH2:11]([C:10]1[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=[CH:8][CH:9]=1)[CH3:12]

Komponenten

4

Edukt 2

HCID 30420161-Chloro-1-penten-3-oneHCID 178418311HCID 178418311, Verbindung

Produkt 1

HCID 189193537-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 3-amino-1,2,4-triazole (11.74 g) and 1-chloro-1-penten-3-one (16.5 g) in acetic acid (225 ml) was heated under reflux for 45 minutes. The reaction mixture was cooled, poured onto ice and extracted with dichloromethane. The organic layer was dried and the solvent was evaporated under reduced pressure to give 7-ethyl-1,2,4-triazolo[1,5-a]pyrimidine. Yield 11.72 g.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 45 minutes
  3. temperatureThe reaction mixture was cooled
  4. additionpoured onto ice
  5. extractionextracted with dichloromethane
  6. customThe organic layer was dried
  7. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0aa344644dc74068b60e34c3e9ed934b
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05753665

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