Benzoyl Peroxide → 7-(1-Bromoethyl)-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1290802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290802
[CH2:1]([C:3]1[N:8]2[N:9]=[CH:10][N:11]=[C:7]2[N:6]=[CH:5][CH:4]=1)[CH3:2].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:12][CH:1]([C:3]1[N:8]2[N:9]=[CH:10][N:11]=[C:7]2[N:6]=[CH:5][CH:4]=1)[CH3:2]

Komponenten

5

Edukt 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 189193537-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

Produkt 1

HCID 189193517-(1-Bromoethyl)-1,2,4-triazolo[1,5-a]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A mixture of 7-ethyl-1,2,4-triazolo[1,5-a]pyrimidine (10.5 g), N-bromosuccinimide (12.63 g), dibenzoylperoxide (0.3 g) and tetrachloromethane (270 ml) was heated under reflux for 5 hours with stirring. The mixture was filtered and a crude product was obtained by evaporation of the solvent from the filtrate. This was purified by recrystallisation from tetrachloromethane to give 7-(1-bromoethyl)-1,2,4-triazolo[1,5-a]pyrimidine. Yield 10.8 g.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. filtrationThe mixture was filtered
  4. customa crude product was obtained by evaporation of the solvent from the filtrate
  5. customThis was purified by recrystallisation from tetrachloromethane

Quellen und Nachweise

ORD-Eintrag
ord-500a3da8126445c6a19de442eeceb3b4
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05753665

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