Sodium Hydroxide → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

HRID 1290897

Reaktionsgleichung

Reaktionsgleichung von HRID 1290897
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:16]CC)=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 15468682Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate

Produkt 1

HCID 109442901-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acidAusbeute 17,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1.55 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate and 0.28 g of sodium hydroxide in 10 ml of ethanol and 2 ml of water was stirred overnight at room temperature. The solvent was distilled off and dil. hydrochloric acid was added to the residue. The precipitated solid was filtered, washed with water and dried to give 0.24 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid.

Aufarbeitung

  1. distillationThe solvent was distilled off
  2. additiondil. hydrochloric acid was added to the residue
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fa87404ba9ff4efb811ae747441d3c4e
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05753673

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