Acetic Acid → 2-Chloro-5-ethylpyridine

HRID 129101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 129101
[N:1]1([CH:6]=[CH:7][C:8]#N)[CH2:5][CH2:4][CH2:3][CH2:2]1.N1(C=CCC)CCCC1.C(O)(=O)C.[ClH:23]>C(Cl)(Cl)Cl>[Cl:23][C:6]1[CH:7]=[CH:8][C:4]([CH2:3][CH3:2])=[CH:5][N:1]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1396491-But-1-enylpyrrolidineHCID 12732581beta-Pyrrolidino-acrylonitrile

Produkt 1

HCID 111263632-Chloro-5-ethylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

19.3 g of β-pyrrolidino-acrylonitrile were added at -10° C. to 30 g of pyrrolidino-butene from A4 in 50 ml of chloroform. The mixture was allowed to warmto RT, and 50 ml of acetic acid were added dropwise. After stirring at RT for 15 hours, the mixture was cooled to -10° C., and dry hydrogen chloride gas was introduced. Aqueous workup gave 2-chloro-5-ethylpyridine as the main product.

Aufarbeitung

  1. customto warmto RT
  2. temperaturethe mixture was cooled to -10° C.

Quellen und Nachweise

ORD-Eintrag
ord-14b569afbedf4364a9df29d744aacb65
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05466800

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