4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 1292243Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1292243
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

Produkt 1

HCID 45247074-BROMO-4'-SULFOBIPHENYLAusbeute 79,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-bromobiphenyl (50 g, 0.21 mol) in chloroform (200 mL) was added dropwise at room temperature chlorosulfonic acid (32.5 g, 0.28 mol). The solution was stirred at room temperature for 16 hours, then diluted with hexanes (200 mL). The precipitate was collected by filtration and washed with hexanes to give 4'-bromobiphenyl-4-sulfonic acid (52.3 g, 79%) as a white solid. The crude product was used in the next step without further characterization.

Aufarbeitung

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with hexanes

Quellen und Nachweise

ORD-Eintrag
ord-a769a92bc2f64a84af08b23594258d81
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05756545

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