Nimesulide → HCID 131720675, Verbindung

HRID 1292321

Reaktionsgleichung

Reaktionsgleichung von HRID 1292321
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N+:19]([O-:21])=[O:20])=[CH:10][C:11]=1[O:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:4])=[O:3].[NH2:22][C@H:23]([C:29]([OH:31])=[O:30])[CH2:24][CH2:25][CH2:26][CH2:27][NH2:28].[CH2:32]([OH:108])[C@H:33]1[O:38][C@@H:37]2[O:39][C@H:40]3[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]4[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]5[C@H:63]([OH:64])[C@@H:62]([OH:65])[C@@H:61]([O:66][C@H:67]6[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:70]([O:75][C@H:76]7[C@H:81]([OH:82])[C@@H:80]([OH:83])[C@@H:79]([O:84][C@H:85]8[C@H:91]([OH:92])[C@@H:90]([OH:93])[C@@H:88]([O:89][C@H:34]1[C@H:35]([OH:107])[C@H:36]2[OH:106])[O:87][C@@H:86]8[CH2:94][OH:95])[O:78][C@@H:77]7[CH2:96][OH:97])[O:69][C@@H:68]6[CH2:98][OH:99])[O:60][C@@H:59]5[CH2:100][OH:101])[O:51][C@@H:50]4[CH2:102][OH:103])[O:42][C@@H:41]3[CH2:104][OH:105]>O>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N+:19]([O-:21])=[O:20])=[CH:10][C:11]=1[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:3])=[O:4].[NH2:22][C@H:23]([C:29]([OH:31])=[O:30])[CH2:24][CH2:25][CH2:26][CH2:27][NH2:28].[CH2:98]([OH:99])[C@H:68]1[O:69][C@@H:70]2[O:75][C@H:76]3[C@H:81]([OH:82])[C@@H:80]([OH:83])[C@@H:79]([O:84][C@H:85]4[C@H:91]([OH:92])[C@@H:90]([OH:93])[C@@H:88]([O:89][C@H:34]5[C@H:35]([OH:107])[C@@H:36]([OH:106])[C@@H:37]([O:39][C@H:40]6[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]7[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]8[C@H:63]([OH:64])[C@@H:62]([OH:65])[C@@H:61]([O:66][C@H:67]1[C@H:72]([OH:73])[C@H:71]2[OH:74])[O:60][C@@H:59]8[CH2:100][OH:101])[O:51][C@@H:50]7[CH2:102][OH:103])[O:42][C@@H:41]6[CH2:104][OH:105])[O:38][C@@H:33]5[CH2:32][OH:108])[O:87][C@@H:86]4[CH2:94][OH:95])[O:78][C@@H:77]3[CH2:96][OH:97]

Komponenten

5

Edukt 3

HCID 4495Nimesulide2×HCID 5962L-Lysine2×HCID 444041beta-Cyclodextrin

Produkt 1

HCID 131720675HCID 131720675, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

6.16 g of nimesulide (2×10-2 mole) are suspended in 200 ml of distilled water to which 6.56 g of L-lysine (4×10-2 mole) are added. The suspension is subjected to ultrasound for 5 minutes and then heated to 50° C. while violent agitation is maintained [Ultraturrax (registered mark)]. 26.3 g of β-CD·10H2O (2×10-2 mole) are dispersed in 200 ml of distilled water and heated to 50° C. The suspension of β-CD is added to the suspension of nimesulide and L-lysine. The agitation is continued for 15 minutes. An orangy solution is obtained.

Aufarbeitung

  1. additionare added
  2. temperatureis maintained [Ultraturrax (registered mark)]
  3. temperatureheated to 50° C
  4. waitThe agitation is continued for 15 minutes
  5. customAn orangy solution is obtained

Quellen und Nachweise

ORD-Eintrag
ord-bf87b3b19c2d42b5a53b4db108ba8a26
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05756546

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