HCID 21254056, Verbindung → HCID 21254080, Verbindung

HRID 1292387Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1292387
C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[C:20]([CH3:25])[CH:19]=1)=[C:12]2[CH2:26][CH2:27][N:28]1[C:36](=[O:37])[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:29]1=[O:38])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[CH3:25][C:20]1[CH:19]=[C:18]([C:13]2[NH:14][C:15]3[C:11]([C:12]=2[CH2:26][CH2:27][N:28]2[C:36](=[O:37])[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[C:29]2=[O:38])=[CH:10][C:9]([OH:8])=[CH:17][CH:16]=3)[CH:23]=[C:22]([CH3:24])[CH:21]=1

Komponenten

5

Edukt 2

HCID 21254056HCID 21254056, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 21254080HCID 21254080, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a stirred solution of 2-[2-[5-benzyloxy-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl]isoindole-1,3-dione (510 mg in 20 mL dry ethyl acetate was added 197 mg of 10% palladium on carbon catalyst. The reaction flask was fitted with a hydrogen balloon, evacuated and recharged with hydrogen (3 times) and stirred at room temperature. After 37 hours the reaction was flushed with nitrogen, filtered over diatomaceous earth and concentrated in vacuo to provide the crude title compound (418 mg).

Aufarbeitung

  1. customevacuated
  2. customAfter 37 hours the reaction was flushed with nitrogen
  3. filtrationfiltered over diatomaceous earth
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-105816a60d854e229a437d458b81769f
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05756507

Notizen zur Reaktion

Wird geladen…