Hydrogen Peroxide → 4-Methoxyimino-5-methylthiochroman-6-carboxylic acid-1,1-dioxide

HRID 1292505

Reaktionsgleichung

Reaktionsgleichung von HRID 1292505
C[O:2]N=C1C2C(=CC=C(C(O)=O)C=2C)SCC1.[CH3:18][O:19][N:20]=[C:21]1[C:30]2[C:25](=[C:26](C)[CH:27]=[C:28]([C:32](C3C=NN(CC)C=3OS(CCC)(=O)=O)=[O:33])[C:29]=2[CH3:31])[S:24](=[O:50])(=[O:49])[CH2:23][CH2:22]1.OO.C(OCC)(=O)C>C(O)(=O)C>[CH3:18][O:19][N:20]=[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([C:32]([OH:33])=[O:2])[C:29]=2[CH3:31])[S:24](=[O:50])(=[O:49])[CH2:23][CH2:22]1

Komponenten

6

Edukt 4

HCID 784Hydrogen PeroxideHCID 8857Ethyl AcetateHCID 537956584-Methoxyimino-5,8-dimethyl-6-(1-ethyl-5-n-propanesulfonyloxypyrazol-4-yl)carbonylthiochroman-1,1-dioxideHCID 539976794-Methoxyimino-5-methylthiochroman-6-carboxylic acid

Produkt 1

HCID 539715404-Methoxyimino-5-methylthiochroman-6-carboxylic acid-1,1-dioxideAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1.0 Gram (4.0 mmol) of the 4-methoxyimino-5-methylthiochroman-6-carboxylic acid obtained in the above (2) was reacted with 1.3 g (12 mmol) of a 30% hydrogen peroxide aqueous solution in 5 ml of acetic acid at 100° C. for 1 hour. Ethyl acetate was added to the reaction product, and the mixture was washed with a saturated sodium chloride aqueous solution and then dried over sodium sulfate. The solvent was distilled off to give 1.1 g (yield 97%) of 4-methoxyimino-5-methylthiochroman-6-carboxylic acid-1,1-dioxide.

Aufarbeitung

  1. washthe mixture was washed with a saturated sodium chloride aqueous solution
  2. dry with materialdried over sodium sulfate
  3. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-b8ab6e12744041b5be5d81e82c49e22b
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05756759

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