Butylethanolamine → 2-[Butyl-(6-methoxy-3-nitro-2-pyridyl)amino]ethanol

HRID 1292702

Reaktionsgleichung

Reaktionsgleichung von HRID 1292702
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.O1CCOCC1.[CH2:19]([NH:23][CH2:24][CH2:25][OH:26])[CH2:20][CH2:21][CH3:22]>O>[CH2:19]([N:23]([C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1)[CH2:24][CH2:25][OH:26])[CH2:20][CH2:21][CH3:22]

Komponenten

5

Edukt 3

HCID 8132ButylethanolamineHCID 312751,4-DioxaneHCID 27950292-Chloro-6-methoxy-3-nitropyridine

Produkt 1

HCID 693354652-[Butyl-(6-methoxy-3-nitro-2-pyridyl)amino]ethanolAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.9 g (0.01 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 30 ml of dioxane, 5 ml of water and 2.62 ml (0.02 mol) of 2-butylaminoethanol are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 1.9 g of yellow powder are obtained, ie a yield of 70%.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 2 hours
  2. stirringwith stirring
  3. customThe precipitate formed
  4. filtrationis filtered off by suction
  5. customdried under vacuum to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-a405500cb4b54119b3ddd3d7e6735b7b
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07238211B2

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