Benzyl Bromide → 4-Benzyloxy dibenzo[b,d]furan-1-carbaldehyde

Temperatur

80 °C

Intermediate 19 (1 gm, 5.10 mmol) was dissolved in dry DMF (10 ml). Anhydrous potassium carbonate (1.05 gm, 7.65 mmol) was added to the above solution and was stirred for 10 min. at 80° C. To this was added benzyl bromide (0.87 gm, 5.10 mmol) and the reaction mixture was stirred for 2 h. The reaction mixture was cooled to room temperature and diluted with water (100 ml) and extracted with ethyl acetate (3×50 ml). The organic extract was washed with water (50 ml) and brine solution (25 ml) and dried over anhydrous sodium sulfate. Removal of solvent gave the product as a brown solid (1.4 gm).

1. stirringthe reaction mixture was stirred for 2 h
2. temperatureThe reaction mixture was cooled to room temperature
3. extractionextracted with ethyl acetate (3×50 ml)
4. extractionThe organic extract
5. washwas washed with water (50 ml) and brine solution (25 ml)
6. dry with materialdried over anhydrous sodium sulfate
7. customRemoval of solvent

ORD-Eintrag

ord-3d637748b5774261b7e6761ed5ec0bd7

Quelldatensatz

uspto-grants-2007_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07238725B2