Water → Methyl 2-hydroxy-5-methoxybenzeneacetate

A mixture of 5-methoxy-2-methoxymethoxybenzaldehyde (9.25 g), methyl methylthiomethyl sulfoxide (11.7 g), 40% solution of benzyltrimethylammonium hydroxide in methanol (10 mL) and tetrahydrofuran (200 mL) heated under reflux for 20 hrs. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated. A mixture of the obtained residue and 10% hydrogen chloride-methanol (80 mL) was heated under reflux for 15 hrs. The reaction mixture was concentrated, and ethyl acetate was added to the residue. The organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated. The obtained residue was subjected to silica gel column chromatography to give crystals (4.88 g, 53%) of methyl 2-(2-hydroxy-5-methoxyphenyl)acetate from a fraction eluted with ethyl acetate-hexane (1:4, v/v). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 69-70° C.

1. temperatureheated
2. temperatureunder reflux for 20 hrs
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated
7. additionA mixture of the obtained residue and 10% hydrogen chloride-methanol (80 mL)
8. temperaturewas heated
9. temperatureunder reflux for 15 hrs
10. concentrationThe reaction mixture was concentrated
11. additionethyl acetate was added to the residue
12. washThe organic layer was washed successively with water and saturated brine
13. dry with materialdried over anhydrous magnesium sulfate
14. concentrationconcentrated

ORD-Eintrag

ord-060c2b2708234daeb7fc88b2f4334ef5

Quelldatensatz

uspto-grants-2007_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07238716B2