Dimethylamine, hydrochloride → 3-[1-(5-Dimethylamino-pyridin-3-yl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

HRID 1294519

Reaktionsgleichung

F[C:2]1[CH:3]=[C:4]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[C:18]#[N:19])[N:10]=[C:9]2[CH3:23])[CH:5]=[N:6][CH:7]=1.Cl.[CH3:25][NH:26][CH3:27]>>[CH3:25][N:26]([CH3:27])[C:2]1[CH:3]=[C:4]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[C:18]#[N:19])[N:10]=[C:9]2[CH3:23])[CH:5]=[N:6][CH:7]=1

Komponenten

Edukt 2

HCID 10473Dimethylamine, hydrochloride

HCID 668792883-[1-(5-Fluoro-pyridin-3-yl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

Produkt 1

HCID 694916663-[1-(5-Dimethylamino-pyridin-3-yl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

Versuchsvorschrift

The title compound, MS: m/e=328.4 (M+), was prepared in accordance with the general method of example 27 from 3-[1-(5-fluoro-pyridin-3-yl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile and dimethylamine hydrochloride.

Quellen und Nachweise

ORD-Eintrag: ord-b2ed5ff836664658b102f6cb0d37ccfe
Quelldatensatz: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07241760B2

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