Hydrochloric Acid → (2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

HRID 1294569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1294569
[F:1][C:2]1[C:3]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8]C(=O)C)[CH:5]=[CH:6][CH:7]=1.Cl.O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[NH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:20]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10340Sodium CarbonateHCID 69489411N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

Produkt 1

HCID 58906377(2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

142 mg (0.52 mmol) N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide are dissolved in 2 ml of ethanol, combined with 2 ml of conc. hydrochloric acid and stirred for 4 h at 70° C. Then the reaction mixture is stirred into 30 ml dist. water, adjusted to pH 7 with sodium carbonate and extracted three times with 10 ml of ethyl acetate. Then the organic phase is dried with MgSO4 and the solvent is eliminated in vacuo.

Aufarbeitung

  1. stirringThen the reaction mixture is stirred into 30 ml dist
  2. extractionextracted three times with 10 ml of ethyl acetate
  3. dry with materialThen the organic phase is dried with MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-fe5e17c8541246c4a9fdfc9f3fed9baa
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07241769B2

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