Hydrazine → 2-(Furan-2-yl)aniline

HRID 1294571

Reaktionsgleichung

Reaktionsgleichung von HRID 1294571
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)([O-])=O.NN>C(O)C.[Pd]>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[NH2:1]

Komponenten

5

Edukt 2

HCID 9321HydrazineHCID 123772252-(2-Nitrophenyl)furan

Produkt 1

HCID 46853502-(Furan-2-yl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

113 mg (0.6 mmol) 2-(2-nitro-phenyl)-furan are dissolved in 2 ml of ethanol and combined with 6 mg palladium on activated charcoal (10% Pd). 110 μl of a 35% aqueous hydrazine solution are added to this suspension and the reaction mixture is stirred for 20 h under reflux conditions. The catalyst is suction filtered, the filtrate is combined with 25 ml of water and adjusted to pH 5. This mixture is extracted three times with 10 ml of ethyl acetate. The combined organic phases are dried and the solvent is eliminated in vacuo.

Aufarbeitung

  1. filtrationfiltered
  2. extractionThis mixture is extracted three times with 10 ml of ethyl acetate
  3. customThe combined organic phases are dried

Quellen und Nachweise

ORD-Eintrag
ord-5c9fa89d29a94b56a8b230fd8def624a
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07241769B2

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