HCID 22570297, Verbindung → Methyl 3-(5-hydroxyindolyl)-2-methylpropanoate

HRID 1295116Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1295116
[CH3:1][CH:2]([CH2:7][C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([O:17]CC1C=CC=CC=1)=[CH:12][CH:11]=2)[C:3]([O:5][CH3:6])=[O:4]>C(O)C.[Pd]>[OH:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH2:7][CH:2]([CH3:1])[C:3]([O:5][CH3:6])=[O:4])=[CH:16]2

Komponenten

4

Edukt 1

HCID 22570297HCID 22570297, Verbindung

Produkt 1

HCID 22570322Methyl 3-(5-hydroxyindolyl)-2-methylpropanoateAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of methyl 2-methyl-3-[5-benzyloxyindolyl]propanoate (0.18 g, 0.56 mmol), as prepared in the preceding step, 10% palladium(0) on carbon (0.018 g) in ethanol (10 mL) was stirred at ambient temperature under hydrogen (balloon) overnight (16 h). The catalyst was removed by filtration through Celite. The filtrate was concentrated to give the title compound as a light brown oil (0.11 g, 85%) which was used directly in the next reaction.

Aufarbeitung

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-5053926935a34cf8afad0bbb8c7dee8e
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07241789B2

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