3-Methyl-4-nitrophenol → Methyl-{6-[2-(3-methyl-4-nitro-phenoxy)-ethyl]-pyridin-2-yl}-carbamic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:18])[N:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][OH:17])[N:10]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[CH3:19][C:20]1[CH:21]=[C:22](O)[CH:23]=[CH:24][C:25]=1[N+:26]([O-:28])=[O:27]>>[C:1]([O:5][C:6](=[O:18])[N:7]([CH3:8])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][O:17][C:22]2[CH:23]=[CH:24][C:25]([N+:26]([O-:28])=[O:27])=[C:20]([CH3:19])[CH:21]=2)[N:10]=1)([CH3:3])([CH3:2])[CH3:4]Komponenten
3
Versuchsvorschrift
The title compound was synthesized from [6-(2-hydroxy-ethyl)-pyridin-2-yl]-methyl-carbamic acid tert-butyl ester and the commercially available 3-methyl-4-nitro-phenol using the procedure described in Example 16, step (b), in 81% yield. 1H NMR (Cl3CD), δ: 1.52 (s, 9H), 2.62 (s, 3H), 3.21 (t, 2H, J=8.00 Hz), 3.36 (s, 3H), 4.44 (t, 2H, J=8.00 Hz), 6.80 (m, 2H), 6.94 (dd, 1H, J=2.4, 5.6 Hz), 7.55 (m, 2H), 8.05 (d, 1H, J=8.8 Hz).
Quellen und Nachweise
- ORD-Eintrag
- ord-b167bd0c7f7c4b65a9c8a3dc497ba83c
- Quelldatensatz
- uspto-grants-2007_07
- Patentnummer
- US07241789B2
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