Hydrochloric Acid → HCID 15225578, Verbindung

HRID 129564Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 129564
C[O:2][CH:3](OC)[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]2[N:17]=[N:18][N:19]([C:21]([CH3:29])([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH3:22])[N:20]=2)=[CH:6][CH:5]=1.Cl.O>CO>[CH3:29][C:21]([N:19]1[N:18]=[N:17][C:16]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:7]2[CH:6]=[CH:5][C:4]([CH:3]=[O:2])=[CH:9][CH:8]=2)=[N:20]1)([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[CH3:22]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 111124504-dimethoxymethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl

Produkt 1

HCID 15225578HCID 15225578, VerbindungAusbeute 97,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 4-dimethoxymethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl (2.9 g, 7.0 mmol) and 15 mL of 4M hydrochloric acid in 50 mL of methanol was stirred at room temperature for 18 hours. The mixture was diluted with 200 mL of diethyl acetate and poured into 300 mL of water. The ethyl acetate layer was washed 3 times with water, dried over magnesium sulfate and concentrated giving a white, waxy solid (2.51 g). A portion of the solid (1.53 g) was crystallized from diethyl ether and isolated. Drying gave 2'-[2-(1-methyl-1-phenylethyl)biphenyl-2H-tetrazolebiphenyl-4-carbaldehyde (1.2 g, 3.2 mmol), m.p. 98.5°-97° C.

Aufarbeitung

  1. washThe ethyl acetate layer was washed 3 times with water
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-221d9271be6d4d36ad99a6fadaaec73f
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05468867

Notizen zur Reaktion

Wird geladen…