Hydrogen Peroxide → HCID 69508634, Verbindung

HRID 1295738Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1295738
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][S:12][CH3:13])[CH:5]=1.[OH:14]O>C(O)(=O)C.C(Cl)Cl.C([O-])([O-])=O.[K+].[K+]>[CH3:13][S:12]([CH2:11][O:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[CH2:3][NH:2][CH3:1])=[O:14]

Komponenten

6

Edukt 2

HCID 784Hydrogen PeroxideHCID 69507792HCID 69507792, Verbindung

Produkt 1

HCID 69508634HCID 69508634, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 11430Potassium CarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Compound from step 3 (592 mg, 3.00 mmol) was dissolved in glacial acetic acid (4 mL) and cooled to 0° C. H2O2 (0.34 mL, 3.00 mmol) was added drop-wise. The mixture was allowed to stir for 6 h. The mixture was then diluted with CH2Cl2 and neutralized with K2CO3. The solids were filtered off. The filtrate was dried over Na2SO4 and concentrated in vacuo to give 640 mg (quant) of a yellow crystalline solid.

Aufarbeitung

  1. filtrationThe solids were filtered off
  2. dry with materialThe filtrate was dried over Na2SO4
  3. concentrationconcentrated in vacuo
  4. customto give 640 mg (quant) of a yellow crystalline solid

Quellen und Nachweise

ORD-Eintrag
ord-b63a465c593a4d1fa77a5b9350631b67
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07244738B2

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