Dimethyl Sulfate → HCID 15125726, Verbindung

HRID 129591

Reaktionsgleichung

Reaktionsgleichung von HRID 129591
[O:1]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.BrC1C=CC=CC=1C=O.COC1C=C(C=CC=1)O[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[CH2:36][C:37]([O:39][CH3:40])=[O:38].CO/C=C(\C1C=CC=CC=1OC1C=CC=C(OC2C=CC=CC=2)C=1)/C(OC)=O.[H-].[Na+].C(OC)=O.C(=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O.OC1C=C(C=CC=1)OC1C=CC=CC=1/C(=C\OC)/C(OC)=O>>[O:1]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[O:14][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[CH2:36][C:37]([O:39][CH3:40])=[O:38])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

10

Edukt 9

HCID 6497Dimethyl SulfateHCID 7865Methyl formateHCID 11430Potassium CarbonateHCID 128423-PhenoxyphenolHCID 24758Sodium hydride2×HCID 811292-BromobenzaldehydeHCID 10861730HCID 10861730, VerbindungHCID 14620154Methyl 2-(3-methoxyphenoxy)benzeneacetateHCID 14620157HCID 14620157, Verbindung

Produkt 1

HCID 15125726HCID 15125726, Verbindung

Versuchsvorschrift

Methyl 2-(3-phenoxyphenoxy)phenylacetate was prepared from 3-phenoxyphenol and 2-bromobenzaldehyde by the steps described in Example 1 for the preparation of methyl 2-(3-methoxyphenoxy)phenylacetate. This was the converted into (E)-methyl 3-methoxy-2-[2-(3-phenoxyphenoxy) phenyl]propenoate [1H n.m.r (250 MHz) 3.61 (3H, s), 3.78 (3H, s), 6.68-7.35 (13H, m), 7.48 (1H, s) ppm] using sodium hydride and methyl formate, and then potassium carbonate and dimethyl sulphate, using the procedure described in Example 1 for the preparation of (E)-methyl 2-[2-(3-hydroxyphenoxy)phenyl]-3-methoxypropenoate, except that just 2 equivalents of sodium hydride were used in this case.

Quellen und Nachweise

ORD-Eintrag
ord-5570be487ca14746a87360442f67b0ac
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05468857

Verknüpfte Notizen

Wird geladen…