CC(OC)(C)C.C(Cl)Cl.[F:10][C:11]1[CH:12]=[C:13]([CH:36]=[C:37]([F:39])[CH:38]=1)[CH2:14][C@H:15]([NH:32][C:33](=[O:35])[CH3:34])[C@H:16]([OH:31])[CH2:17][NH:18][C@@H:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][CH3:30])[CH:27]=2)[O:22][CH2:21][CH2:20]1.Cl>CCOCC.CO>[F:10][C:11]1[CH:12]=[C:13]([CH:36]=[C:37]([F:39])[CH:38]=1)[CH2:14][C@H:15]([NH:32][C:33](=[O:35])[CH3:34])[C@H:16]([OH:31])[CH2:17][NH:18][CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][CH3:30])[CH:27]=2)[O:22][CH2:21][CH2:20]1To a MTBE (20 ml), CH2Cl2 (5 ml), MeOH (0.5 ml) solution of N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4S)-6-ethyl-3,4-dihydro-2H-chromen-4-yl]amino}-2-hydroxypropyl)acetamide (0.2 g, 0.5 mmol) was added 1N HCl in Et2O (0.38 ml) and the mixture stirred at room temperature. The final white solid was isolated by removing the solvent and tritration with Et2O. HRMS (ESI+) calcd for C23H28F2N2O3 m/z 419.2146 (M+H)+. Found 419.2166.
Wird geladen…